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課程名稱 |
物理化學下
Physical Chemistry (2) |
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開課學期 |
111-2 |
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授課對象 |
生物資源暨農學院 農業化學系 |
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授課教師 |
馬左仲 |
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課號 |
Chem3008 |
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課程識別碼 |
203E33102 |
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班次 |
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學分 |
3.0 |
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全/半年 |
全年 |
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必/選修 |
必帶 |
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上課時間 |
星期二3,4(10:20~12:10)星期四2(9:10~10:00) |
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上課地點 |
新203新203 |
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備註 |
本課程以英語授課。詳化學系選課須知。先修科目:普通化學。
限本系所學生(含輔系、雙修生) 且 限學士班學生
總人數上限：80人 |
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課程簡介影片 |
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核心能力關聯 |
本課程尚未建立核心能力關連 |
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課程大綱
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為確保您我的權利,請尊重智慧財產權及不得非法影印
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課程概述 |
In this course, the principles of physical chemistry, and in particular
reaction kinetics, will be introduced through the prism of biological
sciences. |
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課程目標 |
By the end of the course, the students will:
1. Understand basic concepts of kinetics in physical chemistry.
2. Be able to correlate these with central biological processes, such as
metabolism, protein synthesis and folding, and enzyme catalysis.
3. Have acquired a working knowledge of basic experimental methods in biophysical chemistry, as well as the mathematical tools used to said experiments. |
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課程要求 |
General Chemistry & Physical Chemistry I |
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預期每週課後學習時數 |
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Office Hours |
每週二 13:00~14:30 |
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指定閱讀 |
Although there are no required readings, as all necessary information will
be provided in the lectures, the course will generally follow chapters 6 to
13 of the text book “Physical Chemistry for the Life Sciences” 2nd Edition,
Atkins & de Paula. |
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參考書目 |
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評量方式
(僅供參考) |
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週次 |
日期 |
單元主題 |
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Week 1 |
2023.02.21 & 2023.02.23 |
Introduction and the Fundamentals: units, constants and basic equations, Reaction rates (Chapter 6), excersises on reaction rates |
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Week 2 |
2023.02.28 & 2023.03.02 |
Holiday on Tuesday Feb. 28th, Excersices on reaction rates on Mar. 2nd. |
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Week 3 |
2023.03.07 2023.03.9 |
Reaction mechanisms I (Chapter 6&7): arrhenius equation, rate determination and experimental methods
Excersise on Arrhenius equation and rate determination |
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Week 4 |
2023.03.14 2023.03.16 |
Reaction mechanisms II (Chapter 7): reaction dynamics and transition state theory |
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Week 5 |
2023.03.21 2023.03.23 |
Enzyme kinetics I: Michaelis Enzymes (Chapter 8)
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Week 6 |
2023.03.28 2023.03.30 |
Enzyme kinetics II: enzyme mechanism, cooperativity and inhibition (Chapter 8)
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Week 7 |
2023.04.04 2023.04.06 |
Holiday and exercises on enzyme kinetics |
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Week 8 |
2023.04.11 2023.04.13 |
Enzyme kinetics III: sequential reactions & biosynthetic pathways (Chapter 8) |
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Week 9 |
2023.04.18 2023.04.20 |
Enzyme kinetics IV: Non-Michaelian reactions. Chemiosmosis & processive enzymes (Chapter 8) |
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Week 10 |
2023.04.25 2023.04.27 |
Physicochemical basis for biophysical experimentation I: Structure of Matter (Chapters 9 and 10)
Mid-term exam on 2023.04.27 |
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Week 11 |
2023.05.02 2023.05.04 |
Biophysical experimentation II: Spectroscopy (Chapter 12) |
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Week 12 |
2023.05.09 2023.05.11 |
Biophysical experimentation III: NMR (Chapter 13)
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Week 13 |
2023.05.16 2023.05.18 |
Biophysical experimentation IV: Principles of X-ray crystallography, data collection (Chapter 11) |
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Week 14 |
2023.05.23 2023.05.25 |
Biophysical experimentation V: Principles of X-ray crystallography, data evaluation (Chapter 11) |
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Week 15 |
2023.05.30 2023.06.01 |
Biophysical experimentation VI: Time-resolved structural biology (Chapter 11) |
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